CALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury
نویسندگان
چکیده
Arnaud Goolaerts, Nadia Pellan-Randrianarison, Jérôme Larghero, Valérie Vanneaux, Yurdagül Uzunhan, Thomas Gille, Nicolas Dard, Carole Planès, Michael A. Matthay, and Christine Clerici Institut National de la Santé et de la Recherche Médicale, U773, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Unité Mixte de Recherche 773 and Unité Mixte de Recherche 940, Paris, France; AP-HP, Hôpital Saint Louis, Unité de Thérapie Cellulaire et CIC de Biothérapies, Paris, France; University Paris Diderot, Sorbonne Paris Cité, Paris, France; Université Paris 13, Sorbonne Paris Cité, EA2363, Bobigny, France; AP-HP, Hôpital Avicenne, Bobigny, France; and AP-HP, Hôpital Bichat, Paris, France
منابع مشابه
Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung.
Recent studies have suggested that bone marrow-derived multipotent mesenchymal stem cells (MSCs) may have therapeutic applications in multiple clinical disorders including myocardial infarction, diabetes, sepsis, and hepatic and acute renal failure. Here, we tested the therapeutic capacity of human MSCs to restore alveolar epithelial fluid transport and lung fluid balance from acute lung injury...
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Among the drug delivery and targeting (DDT) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. However, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. Thus, in the current study, impact of dexamethason...
متن کاملModulation of cellular transport characteristics of the human lung alveolar epithelia
Among the drug delivery and targeting (DDT) routes, lung alveolar epithelium has been given enormous attentions in terms of the delivery of a wide range of macromolecules such as gene- or protein-based nanopharmaceuticals. However, little is known about cellular modulation of lung transport characteristics by endogenous and/or exogenous agents. Thus, in the current study, impact of dexamethason...
متن کاملCALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation
D. F. McAuley,* G. F. Curley,* U. I. Hamid, J. G. Laffey, J. Abbott, D. H. McKenna, X. Fang, M. A. Matthay, and J. W. Lee Centre for Infection and Immunity, The Queen’s University of Belfast, Belfast, Northern Ireland; Department of Anestheisa, St. Michael’s Hospital, and the Keenan Research Centre for Biomedical Science of St. Michael’s Hospital, University of Toronto, Toronto, Canada; Departm...
متن کاملCALL FOR PAPERS Translational Research in Acute Lung Injury and Pulmonary Fibrosis Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner
Tsubouchi H, Yanagi S, Miura A, Iizuka S, Mogami S, Yamada C, Hattori T, Nakazato M. Rikkunshito ameliorates bleomycininduced acute lung injury in a ghrelin-independent manner. Am J Physiol Lung Cell Mol Physiol 306: L233–L245, 2014. First published November 27, 2013; doi:10.1152/ajplung.00096.2013.—Acute lung injury (ALI) is a critical syndrome consisting of acute respiratory failure associate...
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